The Co-Evaluation of Ovarian Epithelium Edema and Oophoritis After the Antioxidant Drug "U-74389G" Effect on Ovarian Ischemia Reperfusion Injury

Aim: This study co-evaluated the 2 quoted histologic variables after the antioxidant lazaroid drug “U-74389G” (L) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic variable of ovarian epithelium edema (OE) or oophoritis (OI) in an induced ischemia reperfusion animal experiment.

Materials and methods: The 2 main experimental endpoints at which the OE and OI scores were evaluated was the 60th reperfusion min (for the groups A and C) and the 120th reperfusion min (for the groups B and D). Specially, the groups A and B were processed without drugs, whereas the groups C andD after L administration.

Results: The first preliminary study showed that L non significantly recessed the OE scores within the “without lesions alterations” grade-0.0634052 [-0.160525 - 0.0337146] (p-value=0.1942). However, the second preliminary study showed that L non significantly increased the OI scores within the “without lesions alterations” grade 0.0454545 [-0.0145524 - 0.1054615] (p-value=0.1334). These 2 studies were co-evaluated since they came from the same experimental setting. This study investigated the combined diagnostic value of both variables together.

Conclusions: L has a hardly recessing potency of these histologic parameters within the “without lesions alterations” grade -0.0089753 [-0.0629372 - 0.0449866] (p-value=0.7382) since they were co-evaluated together.

Keywords: ischemia, ovarian epithelium edema, oophoritis, U-74389G, reperfusion.